Blog: Research

Sanofi MS drug results set stage for extensive late-stage testing

12 February 2020
Pippa Vincent-Cooke

Source Biopharmadive.com: With positive results from a mid-stage study in hand, Sanofi is pushing an experimental multiple sclerosis drug into an extensive late-stage research program comprised of four studies scheduled to begin in the middle of this year.

Gene Variants Linked to High Childhood BMI Point to Higher MS Risk, Study Finds

12 February 2020
Pippa Vincent-Cooke

Source Multiple Sclerosis News Today: Genetic variations that increase body mass index (BMI) in childhood are associated with a higher risk of multiple sclerosis (MS) regardless of a person’s vitamin D levels, a study found.

Multiple Sclerosis Drugs Might Not Need To Reach the Brain To Have Clinical Efficacy

12 February 2020
Pippa Vincent-Cooke

Source Technology Networks: Scientists from Trinity College Dublin have made an important discovery that could lead to more effective treatments for people living with multiple sclerosis (MS) and other autoimmune diseases such as psoriasis and rheumatoid arthritis.

Efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis (MS-SMART)

24 January 2020
Pippa Vincent-Cooke

Source The Lancet: Neurodegeneration is the pathological substrate that causes major disability in secondary progressive multiple sclerosis. A synthesis of preclinical and clinical research identified three neuroprotective drugs acting on different axonal pathobiologies. We aimed to test the efficacy of these drugs in an efficient manner with respect to time, cost, and patient resource.

Siponimod licensed for secondary progressive MS

24 January 2020
Pippa Vincent-Cooke

Source MS Society: This week the European Medicines Agency (EMA) granted a license for siponimod (brand name Mayzent) to treat adults with secondary progressive MS with active disease.

Autologous Hematopoietic Stem Cell Transplantation versus Best Available Therapy for Multiple Sclerosis

21 January 2020
Pippa Vincent-Cooke

Source Multiple Sclerosis News Today: Regeneration in the brain is reduced in people with primary progressive multiple sclerosis (PPMS), but enhanced during disease activity in those with relapsing-remitting MS (RRMS), a study reports.

Brain Regeneration Impaired in Progressive MS, Unaffected By DMTs, Study Reports

21 January 2020
Pippa Vincent-Cooke

Source Multiple Sclerosis News Today: Regeneration in the brain is reduced in people with primary progressive multiple sclerosis (PPMS), but enhanced during disease activity in those with relapsing-remitting MS (RRMS), a study reports.

From depression to dementia, inflammation is medicine’s new frontier

21 January 2020
Pippa Vincent-Cooke

Source The Guardian: The barrier between mind and body appears to be crumbling. Clinical practice and public perception need to catch up.

Unlikely as it may seem, #inflammation has become a hashtag. It seems to be everywhere suddenly, up to all sorts of tricks. Rather than simply being on our side, fighting infections and healing wounds, it turns out to have a dark side as well: the role it plays in causing us harm.

It’s now clear that inflammation is part of the problem in...

MS Progression Affected by Degree of Relapse Recovery and Timing of DMT Use, Study Says

21 January 2020
Pippa Vincent-Cooke

Source Multiple Sclerosis News Today: Recovering well after a first relapse and starting a disease-modifying therapy (DMT) immediately afterwards considerably increases the likelihood of slowing progression in multiple sclerosis (MS), a study suggests.

Its findings support relapse recovery as a critical factor for DMT initiation, and one that should be assessed routinely in MS clinical trials, researchers said.

The study, “Relapse recovery: The forgotten variable in multiple...

New Study Asks: When Does MS Begin?

21 January 2020
Pippa Vincent-Cooke

Source National Multiple Sclerosis Society: Researchers from the Harvard T.H. Chan School of Public Health in Boston and collaborators report on a study that examined blood (serum) samples from 60 military personnel who went on to develop multiple sclerosis years later. Compared to samples from a control group, those who eventually developed MS showed higher than usual levels of a molecule (neurofilament light chain - NfL) that reflects damage to the nervous system.

The levels of NfL...

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